Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC029
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-11 08:51
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250m g 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 39 individuals with a value less than 0.71 were subsequently diagnosed with PD. That is, 92.86% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.71 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 2, 'TN': 4, 'TP': 40, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 7
timePerCircleMean 5.45143
timePerCircleCoV 0.208129
timePerCircleSlope -0.0901468
meanError 1.72875
tremorFreq 6.83594
tremorRelPower 28.8427
tremorGyroAmpMean 0.0122601
tremorGyroAmpSlope 0.0126264
tremorGyroAmpCoV 0.340054
tremorCoordAmpMean 0.0448181
tremorCoordAmpSlope 0.00964213
tremorCoordAmpCoV 0.24052
tremorAccAmpMean 0.0317417
tremorAccAmpSlope 0.00887878
tremorAccAmpCoV 0.327407
tremorPcRelVar 0.641375
tremorPcX -0.475151
tremorPcY -0.879904

Circle Segment 1

Duration 7.4 s, Accuracy Estimate 1.206 (lower is better)

Circle Segment 2

Duration 6.4 s, Accuracy Estimate 1.214 (lower is better)

Circle Segment 3

Duration 5.52 s, Accuracy Estimate 1.609 (lower is better)

Circle Segment 4

Duration 4.84 s, Accuracy Estimate 1.91 (lower is better)

Circle Segment 5

Duration 5.36 s, Accuracy Estimate 1.932 (lower is better)

Circle Segment 6

Duration 4.52 s, Accuracy Estimate 1.691 (lower is better)

Circle Segment 7

Duration 4.12 s, Accuracy Estimate 2.541 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 15.568
timePerSpiralCoV 0.119731
timePerSpiralSlope -0.00529447
meanError 1.78847
tremorFreq 6.64062
tremorRelPower 29.6869
tremorGyroAmpMean 0.015007
tremorGyroAmpSlope -0.000552493
tremorGyroAmpCoV 0.349274
tremorCoordAmpMean 0.0582306
tremorCoordAmpSlope -0.00135774
tremorCoordAmpCoV 0.790479
tremorAccAmpMean 0.0414545
tremorAccAmpSlope 2.29327e-05
tremorAccAmpCoV 0.328691
tremorPcRelVar 0.607537
tremorPcX -0.36955
tremorPcY 0.929211

Spiral Segment 1

Duration 19.36 s, Accuracy Estimate 1.648 (lower is better)

Spiral Segment 2

Duration 14.72 s, Accuracy Estimate 1.98 (lower is better)

Spiral Segment 3

Duration 13.84 s, Accuracy Estimate 1.841 (lower is better)

Spiral Segment 4

Duration 16.36 s, Accuracy Estimate 1.643 (lower is better)

Spiral Segment 5

Duration 14.44 s, Accuracy Estimate 1.895 (lower is better)

Spiral Segment 6

Duration 14.52 s, Accuracy Estimate 1.76 (lower is better)

Spiral Segment 7

Duration 13.84 s, Accuracy Estimate 1.89 (lower is better)

Spiral Segment 8

Duration 15.16 s, Accuracy Estimate 1.849 (lower is better)

Spiral Segment 9

Duration 18.2 s, Accuracy Estimate 1.568 (lower is better)

Spiral Segment 10

Duration 15.24 s, Accuracy Estimate 1.812 (lower is better)

Elel

eDurationMean 0.371216
eDurationStd 0.111905
eDurationStdnorm 0.301456
eDurationMedian 0.345
eDurationQuartdelta 0.1125
eDurationQuartdeltanorm 0.326087
eDurationKurt 5.97074
eDurationTrenddiff -0.115
eDurationTrendratio 0.719512
eWidthMean 5.20492
eWidthStd 1.60319
eWidthStdnorm 0.308013
eWidthMedian 4.914
eWidthQuartdelta 2.3985
eWidthQuartdeltanorm 0.488095
eWidthKurt 2.32674
eWidthTrenddiff -0.585
eWidthTrendratio 0.885057
eHeightMean 9.41692
eHeightStd 2.16259
eHeightStdnorm 0.229649
eHeightMedian 8.775
eHeightQuartdelta 2.95425
eHeightQuartdeltanorm 0.336667
eHeightKurt 2.3977
eHeightTrenddiff -1.2285
eHeightTrendratio 0.872727
eAspectMean 0.553108
eAspectStd 0.112407
eAspectStdnorm 0.203229
eAspectMedian 0.573034
eAspectQuartdelta 0.159438
eAspectQuartdeltanorm 0.278234
eAspectKurt 2.61844
eAspectTrenddiff -0.0725582
eAspectTrendratio 0.877397
eSlantMean 0.212444
eSlantStd 0.140093
eSlantStdnorm 0.659436
eSlantMedian 0.185714
eSlantQuartdelta 0.219052
eSlantQuartdeltanorm 1.17951
eSlantKurt 2.39082
eSlantTrenddiff 0.0125343
eRtopMean 0.816949
eRtopStd 0.111638
eRtopStdnorm 0.136652
eRtopMedian 0.833333
eRtopQuartdelta 0.141175
eRtopQuartdeltanorm 0.16941
eRtopKurt 4.86677
eRtopTrenddiff 0.0886104
eRbotMean 0.436944
eRbotStd 0.177843
eRbotStdnorm 0.407016
eRbotMedian 0.414634
eRbotQuartdelta 0.228586
eRbotQuartdeltanorm 0.551296
eRbotKurt 2.46344
eRbotTrenddiff 0.0153885
eRrightMean 0.933857
eRrightStd 0.0585128
eRrightStdnorm 0.0626571
eRrightMedian 0.933333
eRrightQuartdelta 0.0692672
eRrightQuartdeltanorm 0.0742149
eRrightKurt 4.40051
eRrightTrenddiff 0.0421983
eRleftMean 0.299013
eRleftStd 0.102711
eRleftStdnorm 0.343501
eRleftMedian 0.293578
eRleftQuartdelta 0.155033
eRleftQuartdeltanorm 0.528081
eRleftKurt 2.8846
eRleftTrenddiff 0.0232124
lDurationMean 0.47725
lDurationStd 0.125606
lDurationStdnorm 0.263187
lDurationMedian 0.45
lDurationQuartdelta 0.15
lDurationQuartdeltanorm 0.333333
lDurationKurt 3.63875
lDurationTrenddiff -0.1475
lDurationTrendratio 0.721698
lWidthMean 9.05288
lWidthStd 1.14136
lWidthStdnorm 0.126077
lWidthMedian 8.9505
lWidthQuartdelta 1.521
lWidthQuartdeltanorm 0.169935
lWidthKurt 3.14648
lWidthTrenddiff -0.8775
lWidthTrendratio 0.907975
lHeightMean 21.8819
lHeightStd 3.02679
lHeightStdnorm 0.138324
lHeightMedian 21.645
lHeightQuartdelta 3.9195
lHeightQuartdeltanorm 0.181081
lHeightKurt 2.77248
lHeightTrenddiff -2.7495
lHeightTrendratio 0.881612
lAspectMean 0.418803
lAspectStd 0.0611592
lAspectStdnorm 0.146033
lAspectMedian 0.414519
lAspectQuartdelta 0.0875167
lAspectQuartdeltanorm 0.211128
lAspectKurt 2.87116
lAspectTrenddiff 0.0216252
lAspectTrendratio 1.05244
lSlantMean 0.245763
lSlantStd 0.073709
lSlantStdnorm 0.299919
lSlantMedian 0.248241
lSlantQuartdelta 0.0981317
lSlantQuartdeltanorm 0.395309
lSlantKurt 3.52786
lSlantTrenddiff 0.0665949
lRtopMean 0.881878
lRtopStd 0.0654484
lRtopStdnorm 0.0742148
lRtopMedian 0.8964
lRtopQuartdelta 0.0911926
lRtopQuartdeltanorm 0.101732
lRtopKurt 2.5179
lRtopTrenddiff 0.0318387
lRbotMean 0.303177
lRbotStd 0.124138
lRbotStdnorm 0.409456
lRbotMedian 0.28557
lRbotQuartdelta 0.152767
lRbotQuartdeltanorm 0.534956
lRbotKurt 3.89998
lRbotTrenddiff -0.0501294
lRrightMean 0.937469
lRrightStd 0.0469328
lRrightStdnorm 0.0500633
lRrightMedian 0.9475
lRrightQuartdelta 0.0579973
lRrightQuartdeltanorm 0.0612109
lRrightKurt 3.18012
lRrightTrenddiff 0.0285845
lRleftMean 0.135598
lRleftStd 0.0356539
lRleftStdnorm 0.262939
lRleftMedian 0.132725
lRleftQuartdelta 0.0534294
lRleftQuartdeltanorm 0.402558
lRleftKurt 2.82174
lRleftTrenddiff -0.0188517

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 1
sumTouchScores 7
meanMovementTime 0.584167
numTouches 7
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.89897
sumTouchScores 15.2825
meanMovementTime 1.09219
numTouches 17
undershootPercentage 5.88235
overshootPercentage 11.7647

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 16.04
timePerZigzagCoV 0.112386
timePerZigzagSlope -0.0431421
meanError 2.3607
tremorFreq 6.15234
tremorRelPower 23.8714
tremorGyroAmpMean 0.0544496
tremorGyroAmpSlope -0.00432598
tremorGyroAmpCoV 0.395638
tremorCoordAmpMean 0.107734
tremorCoordAmpSlope 0.00072411
tremorCoordAmpCoV 0.323218
tremorAccAmpMean 0.111552
tremorAccAmpSlope 0.000381791
tremorAccAmpCoV 0.221394
tremorPcRelVar 0.842755
tremorPcX 0.00808923
tremorPcY 0.999967

ZigZag Segment 1

Duration 19.2 s, Accuracy Estimate 2.532 (lower is better)

ZigZag Segment 2

Duration 15.08 s, Accuracy Estimate 2.201 (lower is better)

ZigZag Segment 3

Duration 15.2 s, Accuracy Estimate 2.385 (lower is better)

ZigZag Segment 4

Duration 14.88 s, Accuracy Estimate 2.146 (lower is better)

ZigZag Segment 5

Duration 15.84 s, Accuracy Estimate 2.54 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 9.272
timePerZigzagCoV 0.131611
timePerZigzagSlope -0.0603969
zigzagHeightMean 47.8113
zigzagHeightCoV 0.03798
zigzagHeightSlope 0.0214097
meanError 0.0447011
tremorFreq 6.34766
tremorRelPower 31.2195
tremorGyroAmpMean 0.0649971
tremorGyroAmpSlope 0.0186892
tremorGyroAmpCoV 0.335753
tremorCoordAmpMean 0.11427
tremorCoordAmpSlope 0.0144935
tremorCoordAmpCoV 0.233899
tremorAccAmpMean 0.101108
tremorAccAmpSlope 0.0127626
tremorAccAmpCoV 0.247283
tremorPcRelVar 0.819929
tremorPcX -0.266854
tremorPcY 0.963737

ZigZag Offset Segment 1

Duration 11.32 s, Accuracy Estimate 0.05 (lower is better)

ZigZag Offset Segment 2

Duration 9.08 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 8.88 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 8.04 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 5

Duration 9.04 s, Accuracy Estimate 0.074 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.71}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5522444064460903}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9119341425882515}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}